Moreover, we detected some other previously identified miR-34c targets including Myb, c-Myc, Bcl2 and MET. Unexpectedly, none of the detected miR-34c targets were negatively regulated by E2F1 as SCF was (Figure 5B), indicating a possible specific effect of E2F1 on miR-34c-SCF axis in CRC cells. Here, E2F1 is linked to colorectal carcinoma.