With respect to tumor suppressor genes, two recent studies have shed light on the role of the ubiquitin ligase F-box and WD repeat domain-containing 7 (FBXW7), and of the protein kinase mitogen-activated protein 3 kinase 4, as negative regulators of mTOR/ZEB1 and p38/NF-κB/Snail pathways, respectively [86,87]. Here, FBXW7 is linked to neoplasm.