RUNX3 and neoplasm: In contrast, some loci have been found hypermethylated with age (e.g., estrogen receptor, interferon γ, insulin-like growth factor II, promoters of tumor-suppressor genes such as lysyl oxidase (LOX), p16INK4a, runt-related transcription factor 3 (RUNX3), and TPA-inducible gene 1 (TIG1)) [14].