CDKN2A and colorectal carcinoma: For instance, the five genes that have been reported to be UM in control tissues are MLH1 (71.7%), DKK2 (69.6%), CDKN2A (68.4%), APC (67.5%) and hsa-mir-342 (67.4%), whereas RUNX3 (58.9%), PCDH10 (55.5%), SFRP5 (52.1%), IGF2 (50.4%) and Hnf1b (50.0%) are HM in CRC cases [56].