Recent studies indicate that changes in DNA methylation of the insulin-like growth factor binding protein-1 (IGFBP1) gene are associated with type 2 diabetes, suggesting that increased IGFBP1 DNA methylation and decreased IGFBP1 serum levels are features of short-duration type 2 diabetes [63]. The gene discussed is IGFBPL1; the disease is type 2 diabetes mellitus.