HSPA8 and Alzheimer disease: Silva et al. [110] investigated the mRNA and promoter DNA methylation levels of two chaperones, heat shock protein family A8 and 9 (HSPA8 and HSPA9), in postmortem brain tissue (entorhinal and auditory cortices and hippocampus) from healthy elderly and AD subjects as well as in the peripheral blood of healthy elderly and AD patients.