TNFRSF10A and neoplasm: DR4 (TRAIL-R1), DR5 (TRAIL-R2) and Fas (CD95/Apo-1) are members of the tumor necrosis factor receptor superfamily (TNFRSF), and ligation of death receptors by binding with cognate death ligands from anti-tumor immune cells induces apoptotic signals into tumor cells [6].