In MCF-7 breast cancer cells engineered to overexpress oncogenic HER2 (MCF-7 HER2) and control vector cells (MCF-7 vec), genistein (100 μM) inhibited the phosphorylation of IκBα, sequestering NF-κB complexes into cytoplasm [61]. Here, NFKB1 is linked to breast carcinoma.