In prostate cancer cells, it has been proved that genistein inhibits expression/accumulation of other pro-angiogenic factors like the hypoxia-inducible factor-1α (HIF-1α), apurinic apyrimidinic endonuclease redox effector factor-1 (APE1/Ref-1) or interleukin-8 (IL-8) [88]. This evidence concerns the gene APEX1 and Familial prostate cancer.