Based on numerous in vitro studies, several pomegranate products and phytoconstituents exhibited cytotoxic, antiproliferative, proapoptotic, antiangiogenic, anti-invasive, and antimetastatic effects against estrogen receptor-positive and -negative breast carcinoma cells [38,39,40,41,42,43,44,45,46,47,48]. This evidence concerns the gene ESR1 and breast carcinoma.