The TSC2 LOVD contains 17 different variants (excluding contiguous exon deletions) mapping to TSC2 exon 25, or to the adjacent intronic sequences; 14 of these (five intronic, two silent, and seven missense variants) are classified as not pathogenic (not causing TSC) and three missense variants (p.K954R, p.S960F, and p.E984Q) are unclassified. This evidence concerns the gene TSC2 and tuberous sclerosis.