Expression of N-cadherin is further increased in tumors with metastatic potential and is up-regulated in many cancers, including breast invasive ductal carcinomas [24, 34, 35], colorectal cancers [36, 37], esophageal squamous cell carcinomas [21], and non-small cell lung cancers [38]. The gene discussed is CDH2; the disease is esophageal squamous cell carcinoma.