MLKL and Lymphadenopathy: Deficiency of both MLKL and caspase-8 did, however, rescue the early skin inflammation in Traf2EKO (Figure 5A and 5B) but the mice could not be aged further because Mlkl-/-Casp8-/- mice develop lymphadenopathy before 15 weeks of age (Alvarez-Diaz et al., personal communication, October 2015).