TNF and infection: This is likely to be due to the susceptibility of NFκB2 deficient mice to opportunistic infections because both Tnf-/-Nfkb2-/- and Traf2EKO/EKONfkb2-/- mice also succumbed to such infections (Figure 10C) and (Shinkura et al., 1996; Yin et al., 2001).