We screened further the endometrial cancer specimens for biomarkers associated with the NRP-1 and/or LKB1 signaling pathway by Western blot analysis: VEGFR2, a co-receptor for NRP-1, which is strongly linked with tumor-promoting phenotypes on one hand, and AMPK, a downstream substrate of the candidate LKB1 tumor suppressor gene. This evidence concerns the gene NRP1 and neoplasm.