LMNA and Hutchinson-Gilford progeria syndrome: At the molecular level, LMNA gene mutations affecting prelamin A processing lead to an acceleration in aging, causing adipose tissue atrophy, bone resorption and other systemic symptoms as described in Mandibuloacral Dysplasia (MAD), Hutchinson-Gilford Progeria Syndrome (HGPS), Familiar Partial Lipodystrophy type 2 (FPLD2) and Restrictive Dermophathy (RD) patients [12].