These data, along with previously published studies, suggest an important role for LPA-LPAR signaling within the tumor microenvironment whereby LPA is likely to act via either LPA-LPAR6 signaling in HCC cells, or via LPA-LPAR1/LPAR3 signaling in hepatic myofibroblasts and hepatic cancer progenitor cells. Here, LPAR1 is linked to hepatocellular carcinoma.