SETD7 and gastric cancer: Although SET7/9 expression was increased in MKN7 and HSC43 cells with a de-methylating reagent, 5-aza-dC treatment (P < 0.01), CGI hypermethylation at the promoter region of SET7/9 was not detected in any of the GC cell lines including them and 25 primary GC tissues examined (Supplementary Figures S2C and S2D).