Loss or weak SET7/9 expression was significantly associated with age (P = 0.028), gender (P < 0.001), Lauren's classification (P < 0.001), Ming's classification (P < 0.005), perineural invasion (P < 0.001), pT stage (P < 0.001), lymph node metastasis (P = 0.038), and pTNM stage (P < 0.01). This evidence concerns the gene SETD7 and metastatic malignant neoplasm in the lymph nodes.