The 5-year overall survival rates of patients with or without mutations in the PI3K/AKT pathway genes were also not significantly different (55.5% vs. 56.4% P=0.529), and those of the two groups of either early gastric cancer (83.3% vs. 88.6%, P=0.977) or advanced gastric cancer (51.4% vs. 49.2%, P=0.303) were also not significantly different. This evidence concerns the gene AKT1 and gastric cancer.