Similar results were obtained in the human lung adenocarcinoma A549 cell model, in which LKB1 inhibited BMP7-induced phospho-Smad1/5/8 more potently and in a more sustained manner, compared to the effect LKB1 had against BMP2 signaling; this effect was stronger at very early time points and weaker at later time points (Figure 2I). The gene discussed is BMP7; the disease is lung adenocarcinoma.