To confirm our mechanistic in vitro results in our in vivo NSCLC xenograft model, we finally performed double immunohistochemical stainings of CD31/VEGFR2 and CD31/Tie2 within the NCl-H460 flank tumors of vehicle-treated and TBMS1-treated mice. The gene discussed is PECAM1; the disease is non-small cell lung carcinoma.