Strikingly, the association between let-7c or let-7i and AGO2 significantly increased in both HCT116 TP53+/+ (Fig. 2A,B) and wild-type RKO human colon cancer cell lines (Fig. 2F) but did not change in DLD1 human colon cancer cell lines that expressed a mutated form of TP53 (Fig. 2F). Here, AGO2 is linked to malignant colon neoplasm.