TTN and familial dilated cardiomyopathy: Considering the accumulated evidence of TTN truncating mutations being the most common cause for hereditary DCM [9–11] together with our observations on low prevalence of potentially disease-causing TTNtv in general population, we emphasize that identifying a TTNtv, especially in the A-band region and affecting all transcripts, have a potentially higher risk of being disease causing than previously anticipated [10].