MYBPC2 and hypertrophic cardiomyopathy: Furthermore, using a single gene model, Meurs & Kuan [28] evaluated the methylation of the CpGs within the exon regions of the skeletal muscle isoform of the myosin binding protein C gene (MYBPC2) and cardiac myosin binding protein C gene (MYBPC3), a common causal gene for hypertrophic cardiomyopathy.