CCL2 and nasopharyngeal carcinoma: Cox multivariate analysis including age, gender, WHO histological grade, T stage, N stage, clinical stage, CCL2 and CCR2 status was performed, which revealed that overexpression of CCR2 was one of the independent prognostic factors of poorer OS (P = 0.012) and DMFS (P = 0.045) of NPC patients (Table 2).