Enhanced c-Myc turnover in response to IFN-γ treatment was also observed in Colo-320 colon carcinoma cells with amplified c-Myc (Supplementary Figure S2B, S2C) and in human 2fTGH fibrosarcoma cells (Figure 4A, 4B), showing that this phenomenon was not unique to U-937 cells. The gene discussed is IFNG; the disease is fibrosarcoma.