We have shown previously that IFN-γ restores TPA-induced differentiation and senescence in U-937 monoblastic tumor cells overexpressing v-Myc, a viral homolog of c-Myc mutated at Thr-58 resulting in protein stabilization [15, 29] (Figure 2A, 2B for an outline of the system). This evidence concerns the gene MYC and neoplasm.