Cytoplasmic relocalization of p27 occurs in response to Akt signaling and other oncogenic stimuli, thereby rendering it unable to target Cdk2 and Myc, and redirect p27 function to regulate RhoA, Rac and cell motility and is generally associated with poor prognosis, high tumor grade or metastasis in several human malignancies [26, 50–3]. The gene discussed is CDKN1B; the disease is neoplasm.