Fourteen HD were located over the known recessive cancer genes CDKN2A, PTEN, RB, SMAD4, NF1, MAP2K4, MSH2, TP53, NF2, MLH1, SMARCB1, PIK3R1, BMPR1A and CDH1, which also showed to be important in our analysis. Here, MSH2 is linked to cancer.