Fourteen HD were located over the known recessive cancer genes CDKN2A, PTEN, RB, SMAD4, NF1, MAP2K4, MSH2, TP53, NF2, MLH1, SMARCB1, PIK3R1, BMPR1A and CDH1, which also showed to be important in our analysis. This evidence concerns the gene RB1 and cancer.