Fourteen HD were located over the known recessive cancer genes CDKN2A, PTEN, RB, SMAD4, NF1, MAP2K4, MSH2, TP53, NF2, MLH1, SMARCB1, PIK3R1, BMPR1A and CDH1, which also showed to be important in our analysis. The gene discussed is CDKN2A; the disease is cancer.