A study conducted in Japan reported that the VEGF-A -2578 CC genotypes were correlated with poor survival in RCC patients compared with -2578 CA or CA+AA genotypes and that the -1154 GG genotype was associated with larger tumors, higher tumor stage, and higher stage grouping than the -1154 GA+AA genotype [28]. The gene discussed is VEGFA; the disease is renal cell carcinoma.