Kjaer-Frifeldt et al. reported that the haplotype combinations of CTC, ACG and ACG, ACG of three VEGF biallelic polymorphisms (-2578C>A, -1498C>T, and -634G>C) were significantly associated with a recurrence of colon cancer within 5 years [53], which is similar to the prognosis of RCC in our study. This evidence concerns the gene VEGFA and malignant colon neoplasm.