TP53 and colorectal adenocarcinoma: When human colorectal adenocarcinoma SW620 cell line endogenously expressing p53R273H was transfected with non-target#1 (negative control, C), p53 (positive control targeting both wtp53 and mutp53, p53) or R273H-#3 (273) siRNAs, proliferation of SW620 cells was reduced by both p53 and 273 siRNAs, compared with the control siRNA (Figure 3A).