NR3C2 and Hypertension: Previously, we and others have identified a pathogenic role for the MR in the development of mouse antibody-dependent glomerulonephritis.[3,5] Conditional gene deletion studies have shown that renal injury in mice with anti-glomerular basement membrane (GBM) glomerulonephritis is mediated by MR signaling in macrophages,[5] Furthermore, kidney damage in this model does not involve hypertension,[16] which can be MR-dependent.