NR3C2 and chronic kidney disease: However, this does not rule out the possibility that BR-4628 treatment may succeed at reducing albuminuria in slower developing forms of glomerulonephritis or other chronic kidney diseases resulting from diabetes or hypertension, where steroidal MR antagonists are known to be effective.[3,6,29] Indeed, one previous study has shown that BR-4628 can inhibit proteinuria in a model of mineralocorticoid-induced hypertension.[13]