The most up-regulated genes in OPT-tm samples were those involved in neurological diseases and in neuronal system development, including L-Dopa Decarboxylase (Ddc, fold change = 172.2) and synaptophisin (Syp, fold change = 31.3), confirming the NE phenotype of anaplastic tumors arising in OPN−/−TRAMP mice. The gene discussed is SYP; the disease is nervous system disorder.