IL13 and asthma: Rehman et al. (2013) reported that the knockdown of TRPV1 using siRNA attenuated allergic inflammation in their IL-13 driven asthma model [25] and Delescluse et al. (2012) also showed that treatment with a TRPV1 antagonist reduced histamine-induced airway hyper-responsiveness in OVA-sensitized guinea pigs [26].