To examine whether transactivation of the ORP150 gene might lead to its induction by MG132 in thyroid cancer 8305C cells, we used a reporter construct containing −1079 to +53 base pairs (bp) of the human ORP150 promoter fused to luciferase (pORP150(−1079/+53)-Luc). The gene discussed is HYOU1; the disease is thyroid gland carcinoma.