Within defined molecular subtypes (i.e. all tumors that harbour mutations in one of the lineage specific genes IDH, CIC, FUBP1, ATRX, TP53, PTEN, EGFR, 1p19q codeletion or alt 7/10, frequency listed in Table 2) tumor grade often remained inversely correlated with survival (Additional file 2: Figure S3, Table 3). Here, IDH2 is linked to neoplasm.