NETO2 and colorectal carcinoma: The results of the multivariate analysis confirmed that NETO2 expression (HR = 1.924, 95 % CI = 1.300-2.848, p = 0.001), TNM stage (HR = 1.878, 95 % CI = 1.313-2.685, p = 0.001), and patient age (HR = 1.875, 95 % CI = 1.225- 2.871, p = 0.004) were independent prognostic factors for patients with CRC (Table 3).