Of note, we observed a significant increase in NETO2 mRNA level (over 2-fold) in 52.6 % (30/57) of the cancerous specimens tested, whereas Oparina et al. reported that only 40 % (4/10) of colon cancer samples showed substantially increased expression of NETO2 mRNA. This evidence concerns the gene NETO2 and malignant colon neoplasm.