ELAVL3 and Alzheimer disease: In that study, it was found that there was a trend showing an increase in the number of neuroblasts (PCNA+/HuC/D+) in the DG of moderate AD brains, but eventually a decrease in the number of immature neurons (HuC/D+) in the DG of patients at the stage of severe AD (Ekonomou et al., 2015).