Contrary to our study, Pak et al. showed that lymph node metastasis was not association with EpCAM overexpression [25], what’s more, Gold et al. reported that EpCAM overexpression was a significant predictor for favorable overall survival and disease free survival [26], and even Pak et al. indicated that EpCAM overexpression was not correlated with overall survival in ADC and SCC. Here, EPCAM is linked to metastatic malignant neoplasm in the lymph nodes.