4EBP1 was also positively associated with genes coupled to diabetes pathways, genes regulated by the transcription factors E2F, USF and SP1, the oncogenes HRAS and HOXB13 and several genes involved in negative regulation of translational initiation (EIF4EBP2, EIF2B3, EIF2C2) (S7 Table). The gene discussed is HOXB13; the disease is diabetes mellitus.