The homozygous variant genotype of TLR1 743 T>C (rs4833095) (OR: 2.96, 95% CI: 1.64–5.32, p = 0.0003) and the combined homozygous and the heterozygous variant genotypes of IL12B G>C (rs6887695) (OR: 1.29, 95% CI: 1.03–1.62, p = 0.03) were associated with increased risk of IBD. The gene discussed is TLR1; the disease is inflammatory bowel disease.