IFNA1 and major depressive disorder: Though major depression typically only develops after many weeks of IFN-α administration, changes in mood, motivation and fatigue (and in some cases feelings of social connection and spatial memory) can be readily observed within hours of IFN-α administration (Dowell et al., 2015) and/or other experimental inflammatory challenges such as Typhoid vaccination (Harrison et al., 2009a, Harrison et al., 2009b, Harrison et al., 2014, Harrison et al., 2015a) and Lipopolysaccharide (LPS) injection (Reichenberg et al., 2001, Eisenberger et al., 2010a, Eisenberger et al., 2010b).