After treatment with 5-Aza, the cell viability of both SiHa and HeLa cells was weakened in a dose-dependent manner (p<0.05)(Fig 4), which demonstrated that demethylation of the SALL3 in promoter region could enhance the expression of SALL3 and lead to a decrease in the cell viability and proliferation capacity of the cervical cancer cell lines SiHa and HeLa. The gene discussed is SALL3; the disease is cervical cancer.