These data showed that transgenes were expressed after viral infection and concomitantly tau was abnormally phosphorylated at pT231/pS235 (M4), and pS262/pS356 (12E8) sites in the cerebral cortex (Fig 5Ag and 5As), the ventricular area (Fig 5Bg and 5Bs), the hippocampus (not shown) and cerebellum (not shown) of AAV1-I1PP2A, but not AAV1-GFP rats (Fig 5Ae, 5Aq, 5Be and 5Bq). The gene discussed is MAPT; the disease is viral infectious disease.