ANGPTL8 and type 2 diabetes mellitus: As shown in Figure 3, three comparisons in two studies [11, 12] detected total betatrophin and indicated that the total circulating betatrophin in T2DM patients was higher than that in the nondiabetic controls (SMD, 0.85; 95% CI, 0.20 to 1.50; P = 0.01).