Immunosenescence is “the key” to human aging, all aging-associated diseases (cancer, Alzheimer’s disease, metabolic diseases, and atherosclerosis) being caused by the chronic inflammation coordinated by oxidative stress and manifested by the increase in the level of proinflammatory cytokines, IL (interleukin)-1, IL-6, IL-17 coded by genes activated by the kappa B transcription factor (TF), NF-kB (nuclear factor kappa B) (43). Here, NFKB1 is linked to cancer.