For example, miR-146b increase with age and repress the senescence-associated proinflammatory cytokines IL-6 and IL-8 Activator of transcription 3 (STAT3) and interleukin-6 (IL-6)-mediated signal transducer could be mechanisms by which chronic inflammation contributes to breast cancer such as a common oncogenic event. The gene discussed is IL6; the disease is breast carcinoma.