A more recent study in glioblastoma identified LGR5 as a marker of poor prognosis and a molecule playing an instrumental role in the survival of brain cancer stem-like cells; stem cell marker CD133+ sorted cells expressed higher levels of LGR5 than the CD133 negative cell populations and upon differentiation, LGR5 expression was significantly repressed (Nakata et al., 2013). The gene discussed is PROM1; the disease is glioblastoma.