Lgr5 is specifically expressed on cancer stem cells (CSCs) and is known to amplify the effect of Wnt/β-catenin signaling by working as a receptor for R-spondins (RSPO), which are well established and influential agonists of the Wnt pathway (Carmon et al., 2012), and known key drivers of oncogenesis (de Lau et al., 2014). This evidence concerns the gene LGR5 and cancer.