A more recent study in glioblastoma identified LGR5 as a marker of poor prognosis and a molecule playing an instrumental role in the survival of brain cancer stem-like cells; stem cell marker CD133+ sorted cells expressed higher levels of LGR5 than the CD133 negative cell populations and upon differentiation, LGR5 expression was significantly repressed (Nakata et al., 2013). Here, LGR5 is linked to brain cancer.