Genetic models of NAFLD include the animals with deficiency in leptin signaling, hepatic lipogenesis, β-oxidation, NF-κB and TNF signaling, and cholesterol signaling etc. (Anstee and Goldin 2006; Kanuri and Bergheim 2013; Nagarajan et al. 2012). Here, NFKB1 is linked to metabolic dysfunction-associated steatotic liver disease.