High EGFR expression has been correlated with tumor size, metastasis and survival.7Oral squamous cell carcinoma in the head and neck region over-expressing EGFR exhibits a higher proportion of complete responses to chemotherapy than other malignancies with low-level EGFR expression.8 Over-expression of EGFR presumably due to higher intrinsic proliferative activity could result in higher sensitivity to drug therapy cytotoxic to cells undergoing mitogenesis.7 The gene discussed is EGFR; the disease is neoplasm.