EGFR and Oral leukoplakia: In the present study, the findings in the expression intensity in cases of the oral submucous fibrosis group exhibited interesting considerations; for example, four (40%) out of ten cases showed a strong expression of EGFR and in the other group comprising oral leukoplakia two (20%) out of ten cases showed strong expression of EGFR; this variability may be due to the atrophy of the epithelium in OSMF, which is attributed to the increased loss of cells from the surface despite increased proliferative activity.