SERPINE1 and obesity due to melanocortin 4 receptor deficiency: In fact, obesity-induced inflammation has been described as metaflammation, that is, a chronic and low-grade inflammatory response initiated by excess nutrients in metabolic cells, where circulating levels of an important number of inflammatory markers, such as C-reactive protein (CRP), haptoglobin, Interleukin-1 (IL-1), Interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), plasminogen activator inhibitor-1 (PAI-1), or tumor necrosis factor-alpha (TNF-α), are increased [1, 29, 30].