Although, according to earlier reports [29, 34, 35], we have shown the impact of traditional risk factors for 8-iso-PGF2α concentration and activity of PON-1 (Table 4), PONase activity and 8-iso-PGF2α concentration remained independent determinants of atherosclerosis severity in multiple linear regression after adjusting age, gender, smoking habits, hypertension diabetes, statin therapy, and HDL-C and TAG concentration (Table 3). This evidence concerns the gene PON1 and atherosclerosis.