In this report, we evaluate alterations in the expression of SERT protein clustering in lymphocytes with respect to the scores in the SAAS anhedonia scale in a population of initially drug naïve depression patients (to avoid any misunderstanding, from here on we use the term depression Total, DT, to refer to the total sample of naïve patients enrolled in the study (n = 38), and Depression I (D-I) and Depression II (D-II) to refer to the two subpopulations) [11]. Here, SLC6A4 is linked to major depressive disorder.