To further scrutinize the mechanistic correlation of NFATc4 and Sox9 expression, we performed chromatin immunoprecipitation (ChIP) analysis in the acinar cell line 266-6 upon activation of EGFR signaling and in primary tumor cells from KrasG12D; p53Δ/wt; pdx1-Cre mice upon TGFβ treatment. Here, PDX1 is linked to neoplasm.