We compared organoid cultures of Barrett epithelium isolated from Barrett esophagus from pL2-IL-1b mice [13] cultivated with CM, Wnt-conditioned CaM, and the coculture with neurons in NBM, the normal organoid cultures in CM being the control groups at seven days and ten days (for composition of media, see Table 1). This evidence concerns the gene IL1B and esophageal adenocarcinoma.