The independent variables associated with UACR were assessed through multiple linear regression analysis; these variables included all the potential confounding factors in this study, such as gender, age, diabetic duration, smoking habit, BMI, hypertension, SBP, DBP, FPG, HbA1c, TG, TC, HDL-C, LDL-C, eGFR, TSH, FT3, FT4, presence or absence of DR, insulin use, ACEI/ARB intake, and statin/fibrate intake. This evidence concerns the gene INS and hypertensive disorder.