The results indicated that high expression of ATAD2 in CRC tissues is closely correlated with tumor size (P < 0.001), serum CEA level (P = 0.012), lymph node metastasis (P = 0.018), liver metastasis (P = 0.025), and clinical stage (P = 0.004). Here, ATAD2 is linked to metastatic malignant neoplasm in the lymph nodes.