AICDA and Burkitt lymphoma: In addition, knockdown Spt6 in human Burkitt’s lymphoma BL2 cells overexpressing mutant AID (JP8Bdel) that lacks C-terminal 16 aa residues, which are critical for CSR but not to SHM (63), abolished SHM and H3K4me3 in Ig VH region and non-Ig AID target genes (23).