NFKB1 and Anhidrotic ectodermal dysplasia: The importance of NFκB signaling in memory development is manifested in EDA-ID (anhidrotic ectodermal dysplasia with immunodeficiency) patients, which carry a gain-of-function mutation of IκBα (an NFκB inhibitor) that leads to impaired NFκB activation and a lack of memory T cells (63).